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    pbpA penicillin-binding protein PbpA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887078, updated on 6-Oct-2023

    Summary

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    Gene symbol
    pbpA
    Gene description
    penicillin-binding protein PbpA
    Locus tag
    Rv0016c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (18759..20234, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene anthranilate synthase component II Neighboring gene serine/threonine-protein kinase PknB Neighboring gene serine/threonine-protein kinase PknA Neighboring gene cell division protein RodA Neighboring gene phosphoserine/threonine phosphatase PstP Neighboring gene FHA domain-containing protein FhaB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transpeptidase PbpA and noncanonical transglycosylase RodA of Mycobacterium tuberculosis play important roles in regulating bacterial cell lengths. Arora D, et al. J Biol Chem, 2018 Apr 27. PMID 29530985, Free PMC Article
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results emphasize the fact that whereas redundant enzymes probably compensate for the absence of RodA or PbpA during in vitro growth, the two proteins play critical roles for the survival of the pathogen inside its host.
      Title: The transpeptidase PbpA and noncanonical transglycosylase RodA of Mycobacterium tuberculosis play important roles in regulating bacterial cell lengths.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    penicillin-binding protein PbpA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      18759..20234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214530.1 penicillin-binding protein PbpA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214530.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A654T784
      Conserved Domains (1) summary
      COG0768
      Location:45 → 490
      FtsI; Cell division protein FtsI/penicillin-binding protein 2 [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WKD1.1

    Gene LinkOut

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